This research examines the transformation of the agro-climatic conditions of the Altai region as a result of climate change. The climate of the Altai region in Russia is sharply continental and characterized by dry air and significant weather variability, both in individual seasons and years. The current study is determined by the lack of detailed area-related analytical generalizations for the territory of the Altai region over the past 30 years. Most of the published data dealing with an integrated analysis of the agro-climatic conditions in the Altai region date back to the late 1960s and early 1970s; in most cases, this data is from climate reference-books based on the generalized data from the first half of the 20th century. To make accurate forecasts and to efficiently manage agricultural production in the Altai region, area-related data on the state and dynamics of agro-climatic changes have been analysed. The results reveal that in the period between 1964 and 2017, significant climatic changes occurred in the territory of the Altai region. These climatic changes affected the growing season length, which increased due to a shift in the dates of the air temperature transition above 10 °C, to earlier dates in spring and to later dates in autumn. Furthermore, the current study also revealed that the foothills of the Altai Mountains are the most moistened parts of the region and the Kulunda lowland is the most arid part. In the Altai region, the accumulated temperatures and amounts of precipitation during the growing season increased significantly, and the values of integrated coefficients and indices that reflect the moisture supply conditions for the territory also changed significantly. Based upon the results, a schematic map of the current precipitation distribution on the Altai region’s territory has been generated. These results and this map may be used to conduct more detailed studies in the field of agro-climatology and to update the current borders of agro-climatic areas and revision of the agro-climatic zonation scheme.