The right to life is a basic and fundamental core human right. Despite the idea that the lives of all human beings are equal under the protection of the law, the special characteristics of the seafarers’ profession suggests that they should be granted additional attention and protection. In recent years, issues related to seafarers’ welfare have moved to the forefront of concern, however, discussion on seafarers’ right to life has drawn little attention. This paper is intended to contribute to knowledge in this aspect by drawing together themes from theoretical policy and governance studies and uses case studies that apply lessons from these disciplines to the practical context of the worldwide shipping industry. Specifically, the discussion clarifies the concept and dimension of the human right to life as well as seafarers’ right to life as a special group of industrial workers, notes the hazardous feature of seafaring as an occupation, identifies the sources of seafarers rights in the related maritime policies and international regulations and illustrates the obligation of the state from the perspective of the ‘flag’ and the ‘port’. The paper finally provides conclusions to the ongoing major issues and suggests a mechanism that should be established to ensure seafarers’ right to life is to be respected.