This paper aims at defining a set of indicators to be applied in port areas on the topics of Occupational Health, Safety, Security (OHSS) and Environment. The techniques used to identify and select the OHSS indicators involved two different approaches: (i) a bottom-up method, where an extended and in-depth analysis was performed in order to assess the current indicators applied by ports and, (ii) a top-down approach, mainly based on legislation and regulations as well as the feedback from stakeholders of the port and shipping industry. The bottom-up approach analysed a total number of 526 ports, allowing the identification of the most frequent indicators used by them. The top-down approach collected valuable opinions and suggestions from the port community members. A consensus between the results obtained in the two approaches was reached in order to provide ports with the most adequate and implementable indicators. The Environmental Performance Indicators (EPIs) have been selected based on the results of previous research projects plus further discussions with port stakeholders. The information provided in this paper can be considered as a preliminary attempt to promote port performance measurement in these four sensitive fields.