Circulating miRNAs: A potential tool to identify severe asthma risk?

Mohammed A Kyyaly, Tilman Sanchez-Elsner, Peijun He, Collin L Sones, S Hasan Arshad, Ramesh J Kurukulaaratchy

Research output: Contribution to journalLetterpeer-review


BACKGROUND: Identifying patients at risk of severe asthma is vitally important given the disproportionate burden of disease imposed by that state. However, biomarkers to support such needs remain elusive.

METHODS: In this letter, we assessed whether specific panels of circulating miRNAs (microRNAs) can differentiate between mild and severe asthma patients as well as between healthy subjects and severe asthma patients.

RESULTS: To our knowledge, the miRNAs identified in our work such as miR-28-3p, miR-16-2-3p, and miR-210-3p have not been previously reported as differentially expressed in the serum of severe asthma patients.

CONCLUSION: Our findings suggest that miRNA expression profiles may have the capability as potential biomarkers that signal the risk of having severe asthma. As such, these findings have significant novelty and merit wider dissemination to facilitate further work in this field.

Original languageEnglish
Article numbere12040
JournalClinical and Translational Allergy
Issue number4
Publication statusPublished - 19 Jun 2021
Externally publishedYes


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