Circulating miRNAs: A potential tool to identify severe asthma risk?

Mohammed A Kyyaly; Tilman Sanchez-Elsner; Peijun He; Collin L Sones; S Hasan Arshad; Ramesh J Kurukulaaratchy

doi:10.1002/clt2.12040

Circulating miRNAs: A potential tool to identify severe asthma risk?

Mohammed A Kyyaly, Tilman Sanchez-Elsner, Peijun He, Collin L Sones, S Hasan Arshad, Ramesh J Kurukulaaratchy

Research output: Contribution to journal › Letter › peer-review

Abstract

BACKGROUND: Identifying patients at risk of severe asthma is vitally important given the disproportionate burden of disease imposed by that state. However, biomarkers to support such needs remain elusive.

METHODS: In this letter, we assessed whether specific panels of circulating miRNAs (microRNAs) can differentiate between mild and severe asthma patients as well as between healthy subjects and severe asthma patients.

RESULTS: To our knowledge, the miRNAs identified in our work such as miR-28-3p, miR-16-2-3p, and miR-210-3p have not been previously reported as differentially expressed in the serum of severe asthma patients.

CONCLUSION: Our findings suggest that miRNA expression profiles may have the capability as potential biomarkers that signal the risk of having severe asthma. As such, these findings have significant novelty and merit wider dissemination to facilitate further work in this field.

Original language	English
Article number	e12040
Journal	Clinical and Translational Allergy
Volume	11
Issue number	4
DOIs	https://doi.org/10.1002/clt2.12040
Publication status	Published - 19 Jun 2021
Externally published	Yes

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@article{57bda7380f004e68b51a8bae2a017af7,

title = "Circulating miRNAs: A potential tool to identify severe asthma risk?",

abstract = "BACKGROUND: Identifying patients at risk of severe asthma is vitally important given the disproportionate burden of disease imposed by that state. However, biomarkers to support such needs remain elusive.METHODS: In this letter, we assessed whether specific panels of circulating miRNAs (microRNAs) can differentiate between mild and severe asthma patients as well as between healthy subjects and severe asthma patients.RESULTS: To our knowledge, the miRNAs identified in our work such as miR-28-3p, miR-16-2-3p, and miR-210-3p have not been previously reported as differentially expressed in the serum of severe asthma patients.CONCLUSION: Our findings suggest that miRNA expression profiles may have the capability as potential biomarkers that signal the risk of having severe asthma. As such, these findings have significant novelty and merit wider dissemination to facilitate further work in this field.",

author = "Kyyaly, {Mohammed A} and Tilman Sanchez-Elsner and Peijun He and Sones, {Collin L} and Arshad, {S Hasan} and Kurukulaaratchy, {Ramesh J}",

note = "{\textcopyright} 2021 The Authors. Clinical and Translational Allergy published by John Wiley and Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology.",

year = "2021",

month = jun,

day = "19",

doi = "10.1002/clt2.12040",

language = "English",

volume = "11",

journal = "Clinical and Translational Allergy",

issn = "2045-7022",

publisher = "John Wiley & Sons Inc.",

number = "4",

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TY - JOUR

T1 - Circulating miRNAs

T2 - A potential tool to identify severe asthma risk?

AU - Kyyaly, Mohammed A

AU - Sanchez-Elsner, Tilman

AU - He, Peijun

AU - Sones, Collin L

AU - Arshad, S Hasan

AU - Kurukulaaratchy, Ramesh J

PY - 2021/6/19

Y1 - 2021/6/19

N2 - BACKGROUND: Identifying patients at risk of severe asthma is vitally important given the disproportionate burden of disease imposed by that state. However, biomarkers to support such needs remain elusive.METHODS: In this letter, we assessed whether specific panels of circulating miRNAs (microRNAs) can differentiate between mild and severe asthma patients as well as between healthy subjects and severe asthma patients.RESULTS: To our knowledge, the miRNAs identified in our work such as miR-28-3p, miR-16-2-3p, and miR-210-3p have not been previously reported as differentially expressed in the serum of severe asthma patients.CONCLUSION: Our findings suggest that miRNA expression profiles may have the capability as potential biomarkers that signal the risk of having severe asthma. As such, these findings have significant novelty and merit wider dissemination to facilitate further work in this field.

AB - BACKGROUND: Identifying patients at risk of severe asthma is vitally important given the disproportionate burden of disease imposed by that state. However, biomarkers to support such needs remain elusive.METHODS: In this letter, we assessed whether specific panels of circulating miRNAs (microRNAs) can differentiate between mild and severe asthma patients as well as between healthy subjects and severe asthma patients.RESULTS: To our knowledge, the miRNAs identified in our work such as miR-28-3p, miR-16-2-3p, and miR-210-3p have not been previously reported as differentially expressed in the serum of severe asthma patients.CONCLUSION: Our findings suggest that miRNA expression profiles may have the capability as potential biomarkers that signal the risk of having severe asthma. As such, these findings have significant novelty and merit wider dissemination to facilitate further work in this field.

UR - https://www.mendeley.com/catalogue/80570c78-4625-3c8a-8017-07a33c4ef4d7/

U2 - 10.1002/clt2.12040

DO - 10.1002/clt2.12040

M3 - Letter

C2 - 34161666

SN - 2045-7022

VL - 11

JO - Clinical and Translational Allergy

JF - Clinical and Translational Allergy

IS - 4

M1 - e12040

ER -

Circulating miRNAs: A potential tool to identify severe asthma risk?

Abstract

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