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Research Output 2014 2019

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Article
2019

Evolution-based screening enables genome-wide prioritization and discovery of DNA repair genes

Brunette, G. J., Jamalruddin, M. A., Baldock, R. A., Clark, N. L. & Bernstein, K. A., 9 Sep 2019, In : Proceedings of the National Academy of Sciences of the United States of America.

Research output: Contribution to journalArticle

DNA Repair
Genome
Homologous Recombination
DNA Damage
Genes

Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint

Bigot, N., Day, M., Baldock, R. A., Watts, F. Z., Oliver, A. W. & Pearl, L. H., 28 May 2019, In : eLife. 8

Research output: Contribution to journalArticle

Phosphorylation
DNA Damage
DNA
S Phase Cell Cycle Checkpoints
Methylation

RAD51D splice variants and cancer-associated mutations reveal XRCC2 interaction to be critical for homologous recombination

Baldock, R. A., Pressimone, C. A., Baird, J. M., Khodakov, A., Luong, T. T., Grundy, M. K., Smith, C. M., Karpenshif, Y., Bratton-Palmer, D. S., Prakash, R., Jasin, M., Garcin, E. B., Gon, S., Modesti, M. & Bernstein, K. A., Apr 2019, In : DNA Repair. 76, p. 99-107 9 p.

Research output: Contribution to journalArticle

Homologous Recombination
Protein Isoforms
Yeast
Mutation
Assays
2018

Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair

Lu, W-T., Hawley, B. R., Skalka, G. L., Baldock, R. A., Smith, E. M., Bader, A. S., Malewicz, M., Watts, F. Z., Wilczynska, A. & Bushell, M., 1 Dec 2018, In : Nature Communications. 9, 1, p. 532

Research output: Contribution to journalArticle

DNA Breaks
DNA Repair
Repair
deoxyribonucleic acid
RNA
2016

Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

Densham, R. M., Garvin, A. J., Stone, H. R., Strachan, J., Baldock, R. A., Daza-Martin, M., Fletcher, A., Blair-Reid, S., Beesley, J., Johal, B., Pearl, L. H., Neely, R., Keep, N. H., Watts, F. Z. & Morris, J. R., Jul 2016, In : Nature Structural and Molecular Biology. 23, 7, p. 647-55 9 p.

Research output: Contribution to journalArticle

Ligases
Ubiquitin
Chromatin
DNA Repair
DNA

Sumoylation of eIF4A2 affects stress granule formation

Jongjitwimol, J., Baldock, R. A., Morley, S. J. & Watts, F. Z., 15 Jun 2016, In : Journal of Cell Science. 129, 12, p. 2407-15 9 p.

Research output: Contribution to journalArticle

Sumoylation
Peptide Initiation Factors
Ribosome Subunits
Heat-Shock Response
Post Translational Protein Processing
2015

ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with γH2AX

Baldock, R. A., Day, M., Wilkinson, O. J., Cloney, R., Jeggo, P. A., Oliver, A. W., Watts, F. Z. & Pearl, L. H., 15 Dec 2015, In : Cell Reports. 13, 10, p. 2081-9 9 p.

Research output: Contribution to journalArticle

Heterochromatin
Automatic teller machines
DNA Damage
Repair
Double-Stranded DNA Breaks
2014

The S. pombe translation initiation factor eIF4G is Sumoylated and associates with the SUMO protease Ulp2

Jongjitwimol, J., Feng, M., Zhou, L., Wilkinson, O., Small, L., Baldock, R., Taylor, D. L., Smith, D., Bowler, L. D., Morley, S. J. & Watts, F. Z., 2014, In : PLoS One. 9, 5, p. e94182

Research output: Contribution to journalArticle

Peptide Initiation Factors
Schizosaccharomyces
translation (genetics)
Peptide Hydrolases
proteinases